Dog Arthritis Disease Modifier User Guides Part 1 – SAMe

Promoting Cartilage Growth with SAM-e

What is SAM-e

S-Adenosyl methionine or SAM-e is a substance produced by the liver and was first discovered by G. L. Cantoni in 1952. SAM-e has many functions. Firstly, it promotes cellular growth and repair. Secondly, it helps in the synthesis of several hormones and neurotransmitters and lastly, studies have shown that SAM-e may help prevent cognitive impairment caused by oxidative damage in brain cells.

SAM-e is a popular main component in many dietary supplements in the United States and Canada. Most of these supplements are formulated for people with liver problems. Nevertheless, they are also used in the treatment of arthritis. SAM-e with its antioxidant benefits can help stop the programmed death of chondrocytes (cartilage cells). This is known as apoptosis. SAM-e can also help reduce pain induced by swelling.

Vet’s Recommendations

While generic SAM-e supplements are available, it is best to try a veterinary brand first such as Vetri-SAM-e.

Vetri-SAM-e is a dietary supplement that is used to maintain the health of a dog’s liver. SAM-e reduces the amount of fat in the liver. Fat is a major cause of the liver becoming inefficient. When the liver is stressed or injured, the organ is not able to produce the necessary amounts of SAM-e and Glutathione.

SAM-e is now used in dog arthritis treatment plans. Its antioxidant properties and its ability to promote cellular growth repair helps in the protection of cartilage in the joints.

Vetri-SAM-e is available in three potencies: 90 milligrams for small dogs, 225 milligrams for medium-sized dogs and 435 milligrams for large dogs.

The recommended dosage depends on the dog’s weight. For Vetri-SAM-e 90 mg, one tablet daily is recommended for dogs that 12 pounds or lighter.

For Vetri-SAM-e 225 mg, one tablet daily is recommended for dogs weighing between 13-34 pounds.

For Vetri-SAM-e 425 mg, one tablet daily is recommended for dogs weighing 35-65 pounds; two tablets daily for dogs weighing between 66-120 pounds; three tablets daily for dogs weighing more than 121 pounds.

When administering Vetri-SAM-e, it is advisable to give it an hour before a meal.

SAM-e supplements are generally safe. Nevertheless, it has been observed that SAM-e may cause diarrhea, an upset stomach, insomnia, allergies or rashes. Some also consider SAM-e as a weak carcinogen.

SAM-e is not advisable for dogs being treated for diabetes as it can lower blood glucose levels and may lead to hypoglycemia. It is also not safe for dogs being treated with Tramadol or other opioids.